The Big C²⁰¹⁰

Laura Linney

Cathy Jamison

John Benjamin Hickey

Sean Tolkey

Oliver Platt

Paul Jamison

Gabriel Basso

Adam Jamison

Phyllis Somerville

Marlene

Gabourey Sidibe

Andrea Jackson

Phill Lewis

Cool pool boss

Michael Chernus

Pastor Rick

Emily Kinney

Emily

Brian d'Arcy James

Tim

Liz Holtan

Amber

Judy Gold

Rabbi

Rebecca Watson

Blonde Woman (uncredited)

E.J. Bonilla

Scott

Angela Lewis

Day Nurse

Cynthia Nixon

Rebecca

Reid Scott

Todd Mauer

Ned Eisenberg

Dr. Volimer

Ann Harada

Brenda

Jessica Cummings

Second Receptionist

John Hillner

Doctor

Anne Senelly Kyle

Cancer Patient (uncredited)

Jeremy McLain

Pedestrian (uncredited)

Brian Dennehy

Dad

Isaac Mizrahi

Self

Kathy Najimy

Cathy's Therapist

Connie Ray

Connie Schuler

Darlene Hunt

Hospice Administrator

Michael Ray Escamilla

Angel

Bianca Amato

Susan Rand

Marceline Hugot

Ina

David Aaron Baker

Priest

David Wilson Barnes

Wesley

Marin Mazzie

Janelle Milson

Jen Sese

Florist

Rosemary Howard

Hospice Visitor (uncredited)

Marisa R. Silver

Fashion Show Guest (uncredited)